Dose–response effects of medical exercise therapy in patients with patellofemoral pain syndrome: a randomised controlled clinical trial

Available online 24 July 2012
Publication year: 2012
Source:Physiotherapy



Objectives To evaluate two different therapeutic exercise regimens in patients with patellofemoral pain syndrome (PFPS). Design Multicentre, randomised controlled clinical trial. Setting Three primary healthcare physiotherapy clinics. Participants Forty-two patients with PFPS were assigned at random to an experimental group or a control group. Forty participants completed the study. Interventions Both groups received three treatments per week for 12 weeks. The experimental group received high-dose, high-repetition medical exercise therapy, and the control group received low-dose, low-repetition exercise therapy. The groups differed in terms of number of exercises, number of repetitions and sets, and time spent performing aerobic/global exercises. Main outcome measures Outcome parameters were pain (measured using a visual analogue scale) and function [measured using the step-down test and the modified Functional Index Questionnaire (FIQ)]. Results At baseline, there were no differences between the groups. After the interventions, there were statistically significant (P <0.05) and clinically important differences between the groups for all outcome parameters, all in favour of the experimental group: −1.6 for mean pain [95% confidence interval (CI) −2.4 to −0.8], 6.5 for step-down test (95% CI 3.8 to 9.2) and 3.1 for FIQ (95% CI 1.2 to 5.0). Conclusion The results indicate that exercise therapy has a dose–response effect on pain and functional outcomes in patients with PFPS. This indicates that high-dose, high-repetition medical exercise therapy is more efficacious than low-dose, low-repetition exercise therapy for this patient group. Registered on http://www.clinicaltrials.gov (identifier: NCT01290705).

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