The treatment-related burden for patients undergoing hematopoietic stem cell transplantation (HSCT) may be relieved by physical exercises.
To summarize and analyze the evidence provided by randomized controlled trials (RCTs) on physical exercise interventions among patients with cancer undergoing HSCT.
PubMed, CINAHL, EMBASE, the Cochrane Library, and PEDro were searched for relevant RCTs up to October 1, 2011.
Two reviewers screened articles on inclusion criteria and indentified relevant RCTs.
Two authors assessed the selected articles for risk of bias (ROB). Data extraction was performed by one reviewer. Meta-analyses were undertaken to estimate the outcomes quality of life (QOL), psychological well-being, and distress and fatigue.
Eleven studies were included with study populations consisting of recipients undergoing either an allogeneic or autologous HSCT (n=734). Four studies had low ROB. The exercise interventions were performed before, during, and/or after hospitalization for the HSCT. Different exercise programs on endurance, resistance, and/or ADL training, progressive relaxation, and stretching were employed. Meta- analyses showed that exercise during hospitalization lead to a higher QOL (WMD: 8.72 [95% CI 3.13, 14.31], P=0.002) and less fatigue (SMD 0.53 [0.16, 0.91], P=0.005) in allogeneic patients at the moment of discharge from the hospital. No marked effects were found for psychological well-being and distress. Individual study results suggested significant positive effects on QOL, fatigue, psychological well-being, and distress and physical functioning.
Prevalent shortcomings in the included studies were the heterogeneity between studies and the lack of blinding of participants, personnel, and outcome assessment.
The results suggest that recipients of HSCT may benefit from physical exercise.
Source: http://ptjournal.apta.org/cgi/content/short/ptj.20120181v1?rss=1
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